Microwave-Assisted Rapid and Regioselective Synthesis of N-(alkoxycarbonylmethyl) Nucleobases in Water
نویسندگان
چکیده
Foi desenvolvido um método fácil e ambientalmente benigno para a preparação de nucleobases N-(etioxicarbonilmetil) e N-(iso-propoxicarbonilmetil), importantes na construção de blocos para Ácidos Nucleicos Peptídicos (ANP). Todas as nucleobases são regiosseletivamente alquiladas e os produtos desejados são obtidos com rendimentos moderados a altos, sob irradiação de microondas por 8 minutos em água como solvente e na presença de Et 3 N como base
منابع مشابه
Microwave-promoted facile and efficient preparation of N-(alkoxycarbonylmethyl) nucleobases--building blocks for peptide nucleic acids.
A simple, rapid, and regioselective approach for the synthesis of N-(methoxy-carbonylmethyl)- and N-(n-propoxycarbonylmethyl) nucleobases was developed. By using DMF as the solvent and in the presence of K2CO3 as the base, all the desired products were obtained in moderate yields within 8 min under microwave irradiation.
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